Antigenic Change in Human Influenza A(H2N2) Viruses Detected by Using Human Plasma from Aged and Younger Adult Individuals
Identifieur interne : 000005 ( 1968/Analysis ); précédent : 000004; suivant : 000006Antigenic Change in Human Influenza A(H2N2) Viruses Detected by Using Human Plasma from Aged and Younger Adult Individuals
Auteurs : Yukimasa Matsuzawa ; Kiyoko Iwatsuki-Horimoto ; Yoshinori Nishimoto ; Yukiko Abe ; Satoshi Fukuyama ; Taiki Hamabata ; Moe Okuda ; Yui Go ; Tokiko Watanabe ; Masaki Imai ; Yasumichi Arai ; Ron A. M. Fouchier ; Seiya Yamayoshi ; Yoshihiro Kawaoka [États-Unis, Japon]Source :
- Viruses [ 1999-4915 ] ; 2019.
Abstract
Human influenza A(H2N2) viruses emerged in 1957 and were replaced by A(H3N2) viruses in 1968. The antigenicity of human H2N2 viruses has been tested by using ferret antisera or mouse and human monoclonal antibodies. Here, we examined the antigenicity of human H2N2 viruses by using human plasma samples obtained from 50 aged individuals who were born between 1928 and 1933 and from 33 younger adult individuals who were born after 1962. The aged individuals possessed higher neutralization titers against H2N2 viruses isolated in 1957 and 1963 than those against H2N2 viruses isolated in 1968, whereas the younger adults who were born between 1962 and 1968 possessed higher neutralization titers against H2N2 viruses isolated in 1963 than those against other H2N2 viruses. Antigenic cartography revealed the antigenic changes that occurred in human H2N2 viruses during circulation in humans for 11 years, as detected by ferret antisera. These results show that even though aged individuals were likely exposed to more recent H2N2 viruses that are antigenically distinct from the earlier H2N2 viruses, they did not possess high neutralizing antibody titers to the more recent viruses, suggesting immunological imprinting of these individuals with the first H2N2 viruses they encountered and that this immunological imprinting lasts for over 50 years.
Url:
DOI: 10.3390/v11110978
PubMed: 31652870
PubMed Central: 6893718
Affiliations:
- Japon, États-Unis
- Région de Kantō, Wisconsin
- Madison (Wisconsin), Tokyo
- Université de Tokyo, Université du Wisconsin à Madison
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PMC:6893718Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Antigenic Change in Human Influenza A(H2N2) Viruses Detected by Using Human Plasma from Aged and Younger Adult Individuals</title><author><name sortKey="Matsuzawa, Yukimasa" sort="Matsuzawa, Yukimasa" uniqKey="Matsuzawa Y" first="Yukimasa" last="Matsuzawa">Yukimasa Matsuzawa</name><affiliation><nlm:aff id="af1-viruses-11-00978">Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan;<email>ymatsuza@ims.u-tokyo.ac.jp</email> (Y.M.);<email>fukuyamarry@gmail.com</email> (S.F.);<email>kk176356@stu-cbms.k.u-tokyo.ac.jp</email> (M.O.);<email>yuigo555@gmail.com</email> (Y.G.);<email>tokiko.watanabe@wisc.edu</email> (T.W.);<email>mimai@ims.u-tokyo.ac.jp</email> (M.I.);<email>yamayo@ims.u-tokyo.ac.jp</email> (S.Y.)</nlm:aff></affiliation></author><author><name sortKey="Iwatsuki Horimoto, Kiyoko" sort="Iwatsuki Horimoto, Kiyoko" uniqKey="Iwatsuki Horimoto K" first="Kiyoko" last="Iwatsuki-Horimoto">Kiyoko Iwatsuki-Horimoto</name><affiliation><nlm:aff id="af1-viruses-11-00978">Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan;<email>ymatsuza@ims.u-tokyo.ac.jp</email> (Y.M.);<email>fukuyamarry@gmail.com</email> (S.F.);<email>kk176356@stu-cbms.k.u-tokyo.ac.jp</email> (M.O.);<email>yuigo555@gmail.com</email> (Y.G.);<email>tokiko.watanabe@wisc.edu</email> (T.W.);<email>mimai@ims.u-tokyo.ac.jp</email> (M.I.);<email>yamayo@ims.u-tokyo.ac.jp</email> (S.Y.)</nlm:aff></affiliation></author><author><name sortKey="Nishimoto, Yoshinori" sort="Nishimoto, Yoshinori" uniqKey="Nishimoto Y" first="Yoshinori" last="Nishimoto">Yoshinori Nishimoto</name><affiliation><nlm:aff id="af2-viruses-11-00978">Center for Supercentenarian Medical Research, Shinjuku-ku, Tokyo 160-8582, Japan;<email>ynishimo@z3.keio.jp</email> (Y.N.);<email>yukiko_abe@keio.jp</email> (Y.A.);<email>yasumich@keio.jp</email> (Y.A.)</nlm:aff></affiliation></author><author><name sortKey="Abe, Yukiko" sort="Abe, Yukiko" uniqKey="Abe Y" first="Yukiko" last="Abe">Yukiko Abe</name><affiliation><nlm:aff id="af2-viruses-11-00978">Center for Supercentenarian Medical Research, Shinjuku-ku, Tokyo 160-8582, Japan;<email>ynishimo@z3.keio.jp</email> (Y.N.);<email>yukiko_abe@keio.jp</email> (Y.A.);<email>yasumich@keio.jp</email> (Y.A.)</nlm:aff></affiliation></author><author><name sortKey="Fukuyama, Satoshi" sort="Fukuyama, Satoshi" uniqKey="Fukuyama S" first="Satoshi" last="Fukuyama">Satoshi Fukuyama</name><affiliation><nlm:aff id="af1-viruses-11-00978">Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan;<email>ymatsuza@ims.u-tokyo.ac.jp</email> (Y.M.);<email>fukuyamarry@gmail.com</email> (S.F.);<email>kk176356@stu-cbms.k.u-tokyo.ac.jp</email> (M.O.);<email>yuigo555@gmail.com</email> (Y.G.);<email>tokiko.watanabe@wisc.edu</email> (T.W.);<email>mimai@ims.u-tokyo.ac.jp</email> (M.I.);<email>yamayo@ims.u-tokyo.ac.jp</email> (S.Y.)</nlm:aff></affiliation></author><author><name sortKey="Hamabata, Taiki" sort="Hamabata, Taiki" uniqKey="Hamabata T" first="Taiki" last="Hamabata">Taiki Hamabata</name><affiliation><nlm:aff id="af1-viruses-11-00978">Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan;<email>ymatsuza@ims.u-tokyo.ac.jp</email> (Y.M.);<email>fukuyamarry@gmail.com</email> (S.F.);<email>kk176356@stu-cbms.k.u-tokyo.ac.jp</email> (M.O.);<email>yuigo555@gmail.com</email> (Y.G.);<email>tokiko.watanabe@wisc.edu</email> (T.W.);<email>mimai@ims.u-tokyo.ac.jp</email> (M.I.);<email>yamayo@ims.u-tokyo.ac.jp</email> (S.Y.)</nlm:aff></affiliation></author><author><name sortKey="Okuda, Moe" sort="Okuda, Moe" uniqKey="Okuda M" first="Moe" last="Okuda">Moe Okuda</name><affiliation><nlm:aff id="af1-viruses-11-00978">Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan;<email>ymatsuza@ims.u-tokyo.ac.jp</email> (Y.M.);<email>fukuyamarry@gmail.com</email> (S.F.);<email>kk176356@stu-cbms.k.u-tokyo.ac.jp</email> (M.O.);<email>yuigo555@gmail.com</email> (Y.G.);<email>tokiko.watanabe@wisc.edu</email> (T.W.);<email>mimai@ims.u-tokyo.ac.jp</email> (M.I.);<email>yamayo@ims.u-tokyo.ac.jp</email> (S.Y.)</nlm:aff></affiliation></author><author><name sortKey="Go, Yui" sort="Go, Yui" uniqKey="Go Y" first="Yui" last="Go">Yui Go</name><affiliation><nlm:aff id="af1-viruses-11-00978">Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan;<email>ymatsuza@ims.u-tokyo.ac.jp</email> (Y.M.);<email>fukuyamarry@gmail.com</email> (S.F.);<email>kk176356@stu-cbms.k.u-tokyo.ac.jp</email> (M.O.);<email>yuigo555@gmail.com</email> (Y.G.);<email>tokiko.watanabe@wisc.edu</email> (T.W.);<email>mimai@ims.u-tokyo.ac.jp</email> (M.I.);<email>yamayo@ims.u-tokyo.ac.jp</email> (S.Y.)</nlm:aff></affiliation></author><author><name sortKey="Watanabe, Tokiko" sort="Watanabe, Tokiko" uniqKey="Watanabe T" first="Tokiko" last="Watanabe">Tokiko Watanabe</name><affiliation><nlm:aff id="af1-viruses-11-00978">Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan;<email>ymatsuza@ims.u-tokyo.ac.jp</email> (Y.M.);<email>fukuyamarry@gmail.com</email> (S.F.);<email>kk176356@stu-cbms.k.u-tokyo.ac.jp</email> (M.O.);<email>yuigo555@gmail.com</email> (Y.G.);<email>tokiko.watanabe@wisc.edu</email> (T.W.);<email>mimai@ims.u-tokyo.ac.jp</email> (M.I.);<email>yamayo@ims.u-tokyo.ac.jp</email> (S.Y.)</nlm:aff></affiliation></author><author><name sortKey="Imai, Masaki" sort="Imai, Masaki" uniqKey="Imai M" first="Masaki" last="Imai">Masaki Imai</name><affiliation><nlm:aff id="af1-viruses-11-00978">Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan;<email>ymatsuza@ims.u-tokyo.ac.jp</email> (Y.M.);<email>fukuyamarry@gmail.com</email> (S.F.);<email>kk176356@stu-cbms.k.u-tokyo.ac.jp</email> (M.O.);<email>yuigo555@gmail.com</email> (Y.G.);<email>tokiko.watanabe@wisc.edu</email> (T.W.);<email>mimai@ims.u-tokyo.ac.jp</email> (M.I.);<email>yamayo@ims.u-tokyo.ac.jp</email> (S.Y.)</nlm:aff></affiliation></author><author><name sortKey="Arai, Yasumichi" sort="Arai, Yasumichi" uniqKey="Arai Y" first="Yasumichi" last="Arai">Yasumichi Arai</name><affiliation><nlm:aff id="af2-viruses-11-00978">Center for Supercentenarian Medical Research, Shinjuku-ku, Tokyo 160-8582, Japan;<email>ynishimo@z3.keio.jp</email> (Y.N.);<email>yukiko_abe@keio.jp</email> (Y.A.);<email>yasumich@keio.jp</email> (Y.A.)</nlm:aff></affiliation></author><author><name sortKey="Fouchier, Ron A M" sort="Fouchier, Ron A M" uniqKey="Fouchier R" first="Ron A. M." last="Fouchier">Ron A. M. Fouchier</name><affiliation><nlm:aff id="af3-viruses-11-00978">Department of Viroscience, Erasmus Medical Center, Doctor Molewaterplein 40, 3015 GD Rotterdam, The Netherlands;<email>r.fouchier@erasmusmc.nl</email></nlm:aff></affiliation></author><author><name sortKey="Yamayoshi, Seiya" sort="Yamayoshi, Seiya" uniqKey="Yamayoshi S" first="Seiya" last="Yamayoshi">Seiya Yamayoshi</name><affiliation><nlm:aff id="af1-viruses-11-00978">Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan;<email>ymatsuza@ims.u-tokyo.ac.jp</email> (Y.M.);<email>fukuyamarry@gmail.com</email> (S.F.);<email>kk176356@stu-cbms.k.u-tokyo.ac.jp</email> (M.O.);<email>yuigo555@gmail.com</email> (Y.G.);<email>tokiko.watanabe@wisc.edu</email> (T.W.);<email>mimai@ims.u-tokyo.ac.jp</email> (M.I.);<email>yamayo@ims.u-tokyo.ac.jp</email> (S.Y.)</nlm:aff></affiliation></author><author><name sortKey="Kawaoka, Yoshihiro" sort="Kawaoka, Yoshihiro" uniqKey="Kawaoka Y" first="Yoshihiro" last="Kawaoka">Yoshihiro Kawaoka</name><affiliation><nlm:aff id="af1-viruses-11-00978">Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan;<email>ymatsuza@ims.u-tokyo.ac.jp</email> (Y.M.);<email>fukuyamarry@gmail.com</email> (S.F.);<email>kk176356@stu-cbms.k.u-tokyo.ac.jp</email> (M.O.);<email>yuigo555@gmail.com</email> (Y.G.);<email>tokiko.watanabe@wisc.edu</email> (T.W.);<email>mimai@ims.u-tokyo.ac.jp</email> (M.I.);<email>yamayo@ims.u-tokyo.ac.jp</email> (S.Y.)</nlm:aff><country>États-Unis</country><placeName><settlement type="city">Madison (Wisconsin)</settlement><region type="state">Wisconsin</region></placeName><orgName type="university" n="3">Université du Wisconsin à Madison</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="af4-viruses-11-00978">Department of Special Pathogens, International Research 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Medicine, University of Wisconsin-Madison, Madison, WI 53706, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName><placeName><settlement type="city">Madison (Wisconsin)</settlement><region type="state">Wisconsin</region></placeName><orgName type="university" n="3">Université du Wisconsin à Madison</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31652870</idno><idno type="pmc">6893718</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893718</idno><idno type="RBID">PMC:6893718</idno><idno type="doi">10.3390/v11110978</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000C49</idno><idno type="wicri:explorRef" wicri:stream="Pmc" 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(Y.G.);<email>tokiko.watanabe@wisc.edu</email> (T.W.);<email>mimai@ims.u-tokyo.ac.jp</email> (M.I.);<email>yamayo@ims.u-tokyo.ac.jp</email> (S.Y.)</nlm:aff></affiliation></author><author><name sortKey="Iwatsuki Horimoto, Kiyoko" sort="Iwatsuki Horimoto, Kiyoko" uniqKey="Iwatsuki Horimoto K" first="Kiyoko" last="Iwatsuki-Horimoto">Kiyoko Iwatsuki-Horimoto</name><affiliation><nlm:aff id="af1-viruses-11-00978">Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan;<email>ymatsuza@ims.u-tokyo.ac.jp</email> (Y.M.);<email>fukuyamarry@gmail.com</email> (S.F.);<email>kk176356@stu-cbms.k.u-tokyo.ac.jp</email> (M.O.);<email>yuigo555@gmail.com</email> (Y.G.);<email>tokiko.watanabe@wisc.edu</email> (T.W.);<email>mimai@ims.u-tokyo.ac.jp</email> (M.I.);<email>yamayo@ims.u-tokyo.ac.jp</email> (S.Y.)</nlm:aff></affiliation></author><author><name sortKey="Nishimoto, Yoshinori" sort="Nishimoto, Yoshinori" uniqKey="Nishimoto Y" first="Yoshinori" last="Nishimoto">Yoshinori Nishimoto</name><affiliation><nlm:aff id="af2-viruses-11-00978">Center for Supercentenarian Medical Research, Shinjuku-ku, Tokyo 160-8582, Japan;<email>ynishimo@z3.keio.jp</email> (Y.N.);<email>yukiko_abe@keio.jp</email> (Y.A.);<email>yasumich@keio.jp</email> (Y.A.)</nlm:aff></affiliation></author><author><name sortKey="Abe, Yukiko" sort="Abe, Yukiko" uniqKey="Abe Y" first="Yukiko" last="Abe">Yukiko Abe</name><affiliation><nlm:aff id="af2-viruses-11-00978">Center for Supercentenarian Medical Research, Shinjuku-ku, Tokyo 160-8582, Japan;<email>ynishimo@z3.keio.jp</email> (Y.N.);<email>yukiko_abe@keio.jp</email> (Y.A.);<email>yasumich@keio.jp</email> (Y.A.)</nlm:aff></affiliation></author><author><name sortKey="Fukuyama, Satoshi" sort="Fukuyama, Satoshi" uniqKey="Fukuyama S" first="Satoshi" last="Fukuyama">Satoshi Fukuyama</name><affiliation><nlm:aff id="af1-viruses-11-00978">Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan;<email>ymatsuza@ims.u-tokyo.ac.jp</email> (Y.M.);<email>fukuyamarry@gmail.com</email> (S.F.);<email>kk176356@stu-cbms.k.u-tokyo.ac.jp</email> (M.O.);<email>yuigo555@gmail.com</email> (Y.G.);<email>tokiko.watanabe@wisc.edu</email> (T.W.);<email>mimai@ims.u-tokyo.ac.jp</email> (M.I.);<email>yamayo@ims.u-tokyo.ac.jp</email> (S.Y.)</nlm:aff></affiliation></author><author><name sortKey="Hamabata, Taiki" sort="Hamabata, Taiki" uniqKey="Hamabata T" first="Taiki" last="Hamabata">Taiki Hamabata</name><affiliation><nlm:aff id="af1-viruses-11-00978">Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan;<email>ymatsuza@ims.u-tokyo.ac.jp</email> (Y.M.);<email>fukuyamarry@gmail.com</email> (S.F.);<email>kk176356@stu-cbms.k.u-tokyo.ac.jp</email> (M.O.);<email>yuigo555@gmail.com</email> (Y.G.);<email>tokiko.watanabe@wisc.edu</email> (T.W.);<email>mimai@ims.u-tokyo.ac.jp</email> (M.I.);<email>yamayo@ims.u-tokyo.ac.jp</email> (S.Y.)</nlm:aff></affiliation></author><author><name sortKey="Okuda, Moe" sort="Okuda, Moe" uniqKey="Okuda M" first="Moe" last="Okuda">Moe Okuda</name><affiliation><nlm:aff id="af1-viruses-11-00978">Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan;<email>ymatsuza@ims.u-tokyo.ac.jp</email> (Y.M.);<email>fukuyamarry@gmail.com</email> (S.F.);<email>kk176356@stu-cbms.k.u-tokyo.ac.jp</email> (M.O.);<email>yuigo555@gmail.com</email> (Y.G.);<email>tokiko.watanabe@wisc.edu</email> (T.W.);<email>mimai@ims.u-tokyo.ac.jp</email> (M.I.);<email>yamayo@ims.u-tokyo.ac.jp</email> (S.Y.)</nlm:aff></affiliation></author><author><name sortKey="Go, Yui" sort="Go, Yui" uniqKey="Go Y" first="Yui" last="Go">Yui Go</name><affiliation><nlm:aff id="af1-viruses-11-00978">Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan;<email>ymatsuza@ims.u-tokyo.ac.jp</email> (Y.M.);<email>fukuyamarry@gmail.com</email> (S.F.);<email>kk176356@stu-cbms.k.u-tokyo.ac.jp</email> (M.O.);<email>yuigo555@gmail.com</email> (Y.G.);<email>tokiko.watanabe@wisc.edu</email> (T.W.);<email>mimai@ims.u-tokyo.ac.jp</email> (M.I.);<email>yamayo@ims.u-tokyo.ac.jp</email> (S.Y.)</nlm:aff></affiliation></author><author><name sortKey="Watanabe, Tokiko" sort="Watanabe, Tokiko" uniqKey="Watanabe T" first="Tokiko" last="Watanabe">Tokiko Watanabe</name><affiliation><nlm:aff id="af1-viruses-11-00978">Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan;<email>ymatsuza@ims.u-tokyo.ac.jp</email> (Y.M.);<email>fukuyamarry@gmail.com</email> (S.F.);<email>kk176356@stu-cbms.k.u-tokyo.ac.jp</email> (M.O.);<email>yuigo555@gmail.com</email> (Y.G.);<email>tokiko.watanabe@wisc.edu</email> (T.W.);<email>mimai@ims.u-tokyo.ac.jp</email> (M.I.);<email>yamayo@ims.u-tokyo.ac.jp</email> (S.Y.)</nlm:aff></affiliation></author><author><name sortKey="Imai, Masaki" sort="Imai, Masaki" uniqKey="Imai M" first="Masaki" last="Imai">Masaki Imai</name><affiliation><nlm:aff id="af1-viruses-11-00978">Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan;<email>ymatsuza@ims.u-tokyo.ac.jp</email> (Y.M.);<email>fukuyamarry@gmail.com</email> (S.F.);<email>kk176356@stu-cbms.k.u-tokyo.ac.jp</email> (M.O.);<email>yuigo555@gmail.com</email> (Y.G.);<email>tokiko.watanabe@wisc.edu</email> (T.W.);<email>mimai@ims.u-tokyo.ac.jp</email> (M.I.);<email>yamayo@ims.u-tokyo.ac.jp</email> (S.Y.)</nlm:aff></affiliation></author><author><name sortKey="Arai, Yasumichi" sort="Arai, Yasumichi" uniqKey="Arai Y" first="Yasumichi" last="Arai">Yasumichi Arai</name><affiliation><nlm:aff id="af2-viruses-11-00978">Center for Supercentenarian Medical Research, Shinjuku-ku, Tokyo 160-8582, Japan;<email>ynishimo@z3.keio.jp</email> (Y.N.);<email>yukiko_abe@keio.jp</email> (Y.A.);<email>yasumich@keio.jp</email> (Y.A.)</nlm:aff></affiliation></author><author><name sortKey="Fouchier, Ron A M" sort="Fouchier, Ron A M" uniqKey="Fouchier R" first="Ron A. M." last="Fouchier">Ron A. M. Fouchier</name><affiliation><nlm:aff id="af3-viruses-11-00978">Department of Viroscience, Erasmus Medical Center, Doctor Molewaterplein 40, 3015 GD Rotterdam, The Netherlands;<email>r.fouchier@erasmusmc.nl</email></nlm:aff></affiliation></author><author><name sortKey="Yamayoshi, Seiya" sort="Yamayoshi, Seiya" uniqKey="Yamayoshi S" first="Seiya" last="Yamayoshi">Seiya Yamayoshi</name><affiliation><nlm:aff id="af1-viruses-11-00978">Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan;<email>ymatsuza@ims.u-tokyo.ac.jp</email> (Y.M.);<email>fukuyamarry@gmail.com</email> (S.F.);<email>kk176356@stu-cbms.k.u-tokyo.ac.jp</email> (M.O.);<email>yuigo555@gmail.com</email> (Y.G.);<email>tokiko.watanabe@wisc.edu</email> (T.W.);<email>mimai@ims.u-tokyo.ac.jp</email> (M.I.);<email>yamayo@ims.u-tokyo.ac.jp</email> (S.Y.)</nlm:aff></affiliation></author><author><name sortKey="Kawaoka, Yoshihiro" sort="Kawaoka, Yoshihiro" uniqKey="Kawaoka Y" first="Yoshihiro" last="Kawaoka">Yoshihiro Kawaoka</name><affiliation><nlm:aff id="af1-viruses-11-00978">Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan;<email>ymatsuza@ims.u-tokyo.ac.jp</email> (Y.M.);<email>fukuyamarry@gmail.com</email> (S.F.);<email>kk176356@stu-cbms.k.u-tokyo.ac.jp</email> (M.O.);<email>yuigo555@gmail.com</email> (Y.G.);<email>tokiko.watanabe@wisc.edu</email> (T.W.);<email>mimai@ims.u-tokyo.ac.jp</email> (M.I.);<email>yamayo@ims.u-tokyo.ac.jp</email> (S.Y.)</nlm:aff><country>États-Unis</country><placeName><settlement type="city">Madison (Wisconsin)</settlement><region type="state">Wisconsin</region></placeName><orgName type="university" n="3">Université du Wisconsin à Madison</orgName></affiliation><affiliation wicri:level="4"><nlm:aff id="af4-viruses-11-00978">Department of Special Pathogens, International Research Center for Infectious Diseases, Institute Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Special Pathogens, International Research Center for Infectious Diseases, Institute Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName><orgName type="university">Université de Tokyo</orgName><placeName><settlement type="city">Tokyo</settlement><region type="province">Région de Kantō</region></placeName><placeName><settlement type="city">Madison (Wisconsin)</settlement><region type="state">Wisconsin</region></placeName><orgName type="university" n="3">Université du Wisconsin à Madison</orgName></affiliation><affiliation wicri:level="2"><nlm:aff id="af5-viruses-11-00978">Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706</wicri:regionArea><placeName><region type="state">Wisconsin</region></placeName><placeName><settlement type="city">Madison (Wisconsin)</settlement><region type="state">Wisconsin</region></placeName><orgName type="university" n="3">Université du Wisconsin à Madison</orgName></affiliation></author></analytic><series><title level="j">Viruses</title><idno type="eISSN">1999-4915</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Human influenza A(H2N2) viruses emerged in 1957 and were replaced by A(H3N2) viruses in 1968. The antigenicity of human H2N2 viruses has been tested by using ferret antisera or mouse and human monoclonal antibodies. Here, we examined the antigenicity of human H2N2 viruses by using human plasma samples obtained from 50 aged individuals who were born between 1928 and 1933 and from 33 younger adult individuals who were born after 1962. The aged individuals possessed higher neutralization titers against H2N2 viruses isolated in 1957 and 1963 than those against H2N2 viruses isolated in 1968, whereas the younger adults who were born between 1962 and 1968 possessed higher neutralization titers against H2N2 viruses isolated in 1963 than those against other H2N2 viruses. Antigenic cartography revealed the antigenic changes that occurred in human H2N2 viruses during circulation in humans for 11 years, as detected by ferret antisera. These results show that even though aged individuals were likely exposed to more recent H2N2 viruses that are antigenically distinct from the earlier H2N2 viruses, they did not possess high neutralizing antibody titers to the more recent viruses, suggesting immunological imprinting of these individuals with the first H2N2 viruses they encountered and that this immunological imprinting lasts for over 50 years.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Neumann, G" uniqKey="Neumann G">G. Neumann</name></author><author><name sortKey="Noda, T" uniqKey="Noda T">T. Noda</name></author><author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y. Kawaoka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nabel, G J" uniqKey="Nabel G">G.J. Nabel</name></author><author><name sortKey="Wei, C J" uniqKey="Wei C">C.J. Wei</name></author><author><name sortKey="Ledgerwood, J E" uniqKey="Ledgerwood J">J.E. Ledgerwood</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Babu, T M" uniqKey="Babu T">T.M. Babu</name></author><author><name sortKey="Perera, R" uniqKey="Perera R">R. Perera</name></author><author><name sortKey="Wu, J T" uniqKey="Wu J">J.T. Wu</name></author><author><name sortKey="Fitzgerald, T" uniqKey="Fitzgerald T">T. Fitzgerald</name></author><author><name sortKey="Nolan, C" uniqKey="Nolan C">C. Nolan</name></author><author><name sortKey="Cowling, B J" uniqKey="Cowling B">B.J. Cowling</name></author><author><name sortKey="Krauss, S" uniqKey="Krauss S">S. Krauss</name></author><author><name sortKey="Treanor, J J" uniqKey="Treanor J">J.J. Treanor</name></author><author><name sortKey="Peiris, M" uniqKey="Peiris M">M. Peiris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kumar, S" uniqKey="Kumar S">S. Kumar</name></author><author><name sortKey="Stecher, G" uniqKey="Stecher G">G. 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Ito</name></author><author><name sortKey="Uraki, R" uniqKey="Uraki R">R. Uraki</name></author><author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y. Kawaoka</name></author><author><name sortKey="Wilson, I A" uniqKey="Wilson I">I.A. Wilson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yamayoshi, S" uniqKey="Yamayoshi S">S. Yamayoshi</name></author><author><name sortKey="Yasuhara, A" uniqKey="Yasuhara A">A. Yasuhara</name></author><author><name sortKey="Ito, M" uniqKey="Ito M">M. Ito</name></author><author><name sortKey="Uraki, R" uniqKey="Uraki R">R. Uraki</name></author><author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y. Kawaoka</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Japon</li><li>États-Unis</li></country><region><li>Région de Kantō</li><li>Wisconsin</li></region><settlement><li>Madison (Wisconsin)</li><li>Tokyo</li></settlement><orgName><li>Université de Tokyo</li><li>Université du Wisconsin à Madison</li></orgName></list><tree><noCountry><name sortKey="Abe, Yukiko" sort="Abe, Yukiko" uniqKey="Abe Y" first="Yukiko" last="Abe">Yukiko Abe</name><name sortKey="Arai, Yasumichi" sort="Arai, Yasumichi" uniqKey="Arai Y" first="Yasumichi" last="Arai">Yasumichi Arai</name><name sortKey="Fouchier, Ron A M" sort="Fouchier, Ron A M" uniqKey="Fouchier R" first="Ron A. M." last="Fouchier">Ron A. M. Fouchier</name><name sortKey="Fukuyama, Satoshi" sort="Fukuyama, Satoshi" uniqKey="Fukuyama S" first="Satoshi" last="Fukuyama">Satoshi Fukuyama</name><name sortKey="Go, Yui" sort="Go, Yui" uniqKey="Go Y" first="Yui" last="Go">Yui Go</name><name sortKey="Hamabata, Taiki" sort="Hamabata, Taiki" uniqKey="Hamabata T" first="Taiki" last="Hamabata">Taiki Hamabata</name><name sortKey="Imai, Masaki" sort="Imai, Masaki" uniqKey="Imai M" first="Masaki" last="Imai">Masaki Imai</name><name sortKey="Iwatsuki Horimoto, Kiyoko" sort="Iwatsuki Horimoto, Kiyoko" uniqKey="Iwatsuki Horimoto K" first="Kiyoko" last="Iwatsuki-Horimoto">Kiyoko Iwatsuki-Horimoto</name><name sortKey="Matsuzawa, Yukimasa" sort="Matsuzawa, Yukimasa" uniqKey="Matsuzawa Y" first="Yukimasa" last="Matsuzawa">Yukimasa Matsuzawa</name><name sortKey="Nishimoto, Yoshinori" sort="Nishimoto, Yoshinori" uniqKey="Nishimoto Y" first="Yoshinori" last="Nishimoto">Yoshinori Nishimoto</name><name sortKey="Okuda, Moe" sort="Okuda, Moe" uniqKey="Okuda M" first="Moe" last="Okuda">Moe Okuda</name><name sortKey="Watanabe, Tokiko" sort="Watanabe, Tokiko" uniqKey="Watanabe T" first="Tokiko" last="Watanabe">Tokiko Watanabe</name><name sortKey="Yamayoshi, Seiya" sort="Yamayoshi, Seiya" uniqKey="Yamayoshi S" first="Seiya" last="Yamayoshi">Seiya Yamayoshi</name></noCountry><country name="États-Unis"><region name="Wisconsin"><name sortKey="Kawaoka, Yoshihiro" sort="Kawaoka, Yoshihiro" uniqKey="Kawaoka Y" first="Yoshihiro" last="Kawaoka">Yoshihiro Kawaoka</name></region><name sortKey="Kawaoka, Yoshihiro" sort="Kawaoka, Yoshihiro" uniqKey="Kawaoka Y" first="Yoshihiro" last="Kawaoka">Yoshihiro Kawaoka</name></country><country name="Japon"><region name="Région de Kantō"><name sortKey="Kawaoka, Yoshihiro" sort="Kawaoka, Yoshihiro" uniqKey="Kawaoka Y" first="Yoshihiro" last="Kawaoka">Yoshihiro Kawaoka</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|wiki= Sante
|area= H2N2V1
|flux= 1968
|étape= Analysis
|type= RBID
|clé= PMC:6893718
|texte= Antigenic Change in Human Influenza A(H2N2) Viruses Detected by Using Human Plasma from Aged and Younger Adult Individuals
}}
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| HfdSelect -Kh $EXPLOR_AREA/Data/1968/Analysis/biblio.hfd \
| NlmPubMed2Wicri -a H2N2V1
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